Anyone interested, you look up Queen Mary's university London, Covidence study, first gives you a list of everyone involved in the study, and you can watch Adrian Martineau telling you about it, what they want to achieve.... basically why some people are so badly affected.
So sorry @clematisdorset I've only just seen the post from you. Mine started with feeling a bit poorly mid evening....not flu like, but felt cold and tired. It was one of our warm summer evenings, so wondered why I felt so cold. By the morning I had the most horrendous headache and started being sick. Was being sick all day, couldn't even keep water down and slept inbetween. This went on during the night and the next morning. I friend phoned me and suggested I took a covid test, I was convinced it was a sickness bug. But when I took the test it went straight across to positive. I felt really ill, still a headache, then started being boiling hot then shivering cold and ached everywhere. My temperature was high too. Even after testing negative I felt very tired and lethargic for weeks. I'm ok now, but definitely don't want that again.
Thank you so much for your reply, @star gaze lily, and I am sorry you had COVID and such a bad bout, at that. I can understand how when the symptoms 'creep up' like that, it would make anyone question exactly what was wrong. It is good you could take the test and and could therefore know categorically what was causing the symptoms. The weeks after, waiting to feel better must have been draining too. I am very glad you are ok now. Definitely not something to be repeated. 💐
I feel like there was a lull during early summer and then the new variants started being published in the media later in the summer, and I thought 'oh no, here we go again'...
Sorry to witness the demise of the forum. 😥😥😥😡😡😡I am Spartacus
Realistically,it lasted 4 weeks practically to the day. It has left me with tinnitus in both ears, very deaf,and another Weird "side effect",I have a few sips of wine,or beer it was Monday (birthday meal) and I feel like I have drunk a bottle!! Something else to tell the study next month!
The yeast Candida albicans can play a part in regulating the immune system.Credit: Eye Of Science/SPL
An imbalance of fungi in the gut could contribute to excessive inflammation in people with severe COVID-19 or long COVID. A study found that individuals with severe disease had elevated levels of a fungus that can activate the immune system and induce long-lasting changes.
The work, published on 23 October in Nature Immunology1, raises the possibility that antifungal treatment could provide some relief to people who are critically ill with COVID-19.
“We know inflammation is driving severe disease,” says Martin Hönigl, a clinical mycology researcher at the Medical University of Graz in Austria, who was not involved in the study. This work, he says, provides a potential mechanism of disease-causing inflammation that might have been overlooked.
Inflammation insights
Trillions of microorganisms live in and on our bodies, helping us to digest food, protecting us from harmful pathogens and more. Although much of the microbiome consists of bacteria, past research has shown that the fungal portion — the mycobiota — interacts with the immune system, too2.
Previous studies have shown that many people with COVID-19 have guts with altered microbial make-ups and disrupted protective barriers, which could allow pathogens to enter the blood3,4. And some individuals critically ill with COVID-19 have contracted dangerous fungal infections in their lungs5.
Immunologist Iliyan Iliev at Weill Cornell Medicine in New York City and his colleagues wanted to further investigate the link between the mycobiota and COVID-19. The researchers examined blood from 91 people hospitalized with the disease in 2020. Almost three-quarters of these people had severe COVID-19, who received more than six litres of supplementary oxygen a minute or invasive mechanical ventilation, whereas the rest had moderate or mild disease.
Compared with 36 individuals who had never tested positive for SARS-CoV-2, people with severe COVID-19 produced about four times as many antibodies against three fungal species commonly found in the gut, including the yeast Candida albicans. A high prevalence of antibodies suggests that these people had elevated amounts of those fungi. Faecal samples collected in early 2021 from 10 people with COVID-19 also showed that they had higher overall levels of gut fungi, especially of Candida species, relative to 10 healthy individuals. For these people, the abundance of Candida was positively correlated with disease severity. The presence of some fungal species, C. albicans in particular, has been shown to activate the immune system6.
In a subset of people with severe COVID-19, the number of antibodies against C. albicans in their blood was linked to the number of immune cells called neutrophils, which can trigger inflammation.
When the researchers infected mice with C. albicans extracted from people with severe COVID-19, and then infected them with SARS-CoV-2, they observed that more neutrophils invaded the animals’ lungs and activated an inflammatory response than in mice with SARS-CoV-2 alone. If they gave these mice an antifungal drug, it lowered the number and activity of neutrophils.
Long-COVID theories
The study also found that people with severe COVID-19 continued to have raised levels of antibodies against C. albicans and neutrophil precursors primed to counter fungi long after they had recovered from the disease — up to one year later in some people. These factors hint that mycobiota changes during a SARS-CoV-2 infection could contribute to inflammation associated with long COVID.
“There’s a number of theories of what might trigger persistent symptoms after COVID,” says Aran Singanayagam, a respiratory immunologist at Imperial College London. “Microbial dysbiosis, either of the gut or the lungs, is one major theory that people are proposing, so I think this adds weight to that theory.”
Researchers agree that more work is needed to probe the link between gut fungi and COVID-19. It remains unclear whether the observed changes to the mycobiota in people with COVID-19 resulted from the disease or preceded it and made people more susceptible, says Singanayagam.
If future studies reveal more about the mechanisms involved, existing antifungal treatments could be repurposed to help people with COVID-19. Iliev hopes that this work will “make people start thinking about those common types of biology that we see in very different diseases and how we can leverage that”.
Really interesting, thanks @punkdoc .Now I find myself wondering if gut microbiome differences might be a factor in why some people get systemic side effects from vaccines and others don't. If anything good is coming out of the whole covid thing, perhaps it's more funding for immunology research.
Doncaster, South Yorkshire. Soil type: sandy, well-drained
That is very interesting ... I remember back in the early 80s a friend had a condition which was attributed in some way to Candida albicans ... all his symptoms were like those of ME ... which my daughter had some years later following a bout of Glandular Fever.
Gardening in Central Norfolk on improved gritty moraine over chalk ... free-draining.
Posts
Mine started with feeling a bit poorly mid evening....not flu like, but felt cold and tired. It was one of our warm summer evenings, so wondered why I felt so cold. By the morning I had the most horrendous headache and started being sick. Was being sick all day, couldn't even keep water down and slept inbetween. This went on during the night and the next morning. I friend phoned me and suggested I took a covid test, I was convinced it was a sickness bug. But when I took the test it went straight across to positive. I felt really ill, still a headache, then started being boiling hot then shivering cold and ached everywhere. My temperature was high too. Even after testing negative I felt very tired and lethargic for weeks.
I'm ok now, but definitely don't want that again.
I feel like there was a lull during early summer and then the new variants started being published in the media later in the summer, and I thought 'oh no, here we go again'...
I had a really bad sore throat with it, but no cough at all.
Inflammation in severe COVID linked to bad fungal microbiome
An imbalance of fungi in the gut could contribute to excessive inflammation in people with severe COVID-19 or long COVID. A study found that individuals with severe disease had elevated levels of a fungus that can activate the immune system and induce long-lasting changes.
The work, published on 23 October in Nature Immunology1, raises the possibility that antifungal treatment could provide some relief to people who are critically ill with COVID-19.
“We know inflammation is driving severe disease,” says Martin Hönigl, a clinical mycology researcher at the Medical University of Graz in Austria, who was not involved in the study. This work, he says, provides a potential mechanism of disease-causing inflammation that might have been overlooked.
Inflammation insights
Trillions of microorganisms live in and on our bodies, helping us to digest food, protecting us from harmful pathogens and more. Although much of the microbiome consists of bacteria, past research has shown that the fungal portion — the mycobiota — interacts with the immune system, too2.
Previous studies have shown that many people with COVID-19 have guts with altered microbial make-ups and disrupted protective barriers, which could allow pathogens to enter the blood3,4. And some individuals critically ill with COVID-19 have contracted dangerous fungal infections in their lungs5.
What triggers severe COVID? Infected immune cells hold clues
Immunologist Iliyan Iliev at Weill Cornell Medicine in New York City and his colleagues wanted to further investigate the link between the mycobiota and COVID-19. The researchers examined blood from 91 people hospitalized with the disease in 2020. Almost three-quarters of these people had severe COVID-19, who received more than six litres of supplementary oxygen a minute or invasive mechanical ventilation, whereas the rest had moderate or mild disease.
Compared with 36 individuals who had never tested positive for SARS-CoV-2, people with severe COVID-19 produced about four times as many antibodies against three fungal species commonly found in the gut, including the yeast Candida albicans. A high prevalence of antibodies suggests that these people had elevated amounts of those fungi. Faecal samples collected in early 2021 from 10 people with COVID-19 also showed that they had higher overall levels of gut fungi, especially of Candida species, relative to 10 healthy individuals. For these people, the abundance of Candida was positively correlated with disease severity. The presence of some fungal species, C. albicans in particular, has been shown to activate the immune system6.
In a subset of people with severe COVID-19, the number of antibodies against C. albicans in their blood was linked to the number of immune cells called neutrophils, which can trigger inflammation.
When the researchers infected mice with C. albicans extracted from people with severe COVID-19, and then infected them with SARS-CoV-2, they observed that more neutrophils invaded the animals’ lungs and activated an inflammatory response than in mice with SARS-CoV-2 alone. If they gave these mice an antifungal drug, it lowered the number and activity of neutrophils.
Long-COVID theories
The study also found that people with severe COVID-19 continued to have raised levels of antibodies against C. albicans and neutrophil precursors primed to counter fungi long after they had recovered from the disease — up to one year later in some people. These factors hint that mycobiota changes during a SARS-CoV-2 infection could contribute to inflammation associated with long COVID.
COVID lockdowns altered babies’ microbiomes
“There’s a number of theories of what might trigger persistent symptoms after COVID,” says Aran Singanayagam, a respiratory immunologist at Imperial College London. “Microbial dysbiosis, either of the gut or the lungs, is one major theory that people are proposing, so I think this adds weight to that theory.”
Researchers agree that more work is needed to probe the link between gut fungi and COVID-19. It remains unclear whether the observed changes to the mycobiota in people with COVID-19 resulted from the disease or preceded it and made people more susceptible, says Singanayagam.
If future studies reveal more about the mechanisms involved, existing antifungal treatments could be repurposed to help people with COVID-19. Iliev hopes that this work will “make people start thinking about those common types of biology that we see in very different diseases and how we can leverage that”.
doi: https://doi.org/10.1038/d41586-023-03295-w
References
When you don't even know who's in the team
S.Yorkshire/Derbyshire border
Gardening in Central Norfolk on improved gritty moraine over chalk ... free-draining.