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clone of a clone of a clone - reducing vigour?

I have some pelargoniums that are maybe tenth generation of cuttings. My original cutting (about 12 years ago) grew to seven foot (in a large pot). My current cuttings seem to be struggling to even get going. I wonder if vigour is lost of generations get further in degrees of separation from the "mother plant". Can you take cuttings or cuttings forever? Thanks
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